cómo se transporta la glucosa través de la membrana celular? diana díaz hernández, luis carlos burgos herrera de la célula para su ingreso requiere una. RESUMEN El transporte de la glucosa a través de la membrana plasmática de a sodio (SGLT) y los sistemas facilitadores del transporte de glucosa (GLUT). Se han descrito dos sistemas de transporte de glucosa y de otros monosacáridos : y los transportadores de glucosa llamados GLUT (glucosa transporters).

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GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. Physiol Behav ; Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1″.

Transportador de glucosa

The key point here was ‘flux coupling’, the cotransport of sodium and glucose in the apical membrane of the small intestinal epithelial cell. Reduced content and preserved translocation of glucose transporter GLUT 4 in white adipose tissue of obese mice. De Vivo’s syndrome, described in convulsive infants with hypoglycorrachia during normoglycaemia, has been attributed to a reduction in the GLUT1 content in endothelial cells at the blood-brain barrier.

Is widely distributed in fetal tissues.

Transportadores de glucosa by Jose Rodriguez on Prezi

Binding of glucose to one site provokes a conformational change associated with transport, and transportadored glucose to the other side of the membrane.


Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. Evidence for a family of human glucose transporter-like proteins.

In the adult, it is expressed at highest levels in erythrocytes and also in the endothelial cells of barrier tissues such as the blood—brain barrier. Cloning and functional expresssion in bacteria of a novel glucose transporter present in liver, intestine, kidney, and B-pancreatic islet cells.

A Cellular And Molecular Approaoch. Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose across the plasma membrane. Vestri S, Machado UF. In obesity, the GLUT4 content is not diminished providing that insulin sensitiveness is preserved. Fructose transporter in human spermatozoa and small intestine is GLUT5. Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.

Molecular biology of mammaliam glucose transporters. GLUT is a type of uniporter transporter protein. Ubiratan Fabres Machado Av. Physiol Rev ; Czech Academy of SciencesPrague,pp. Wright and Eric Turk. Mammaliam facilitative glucose transporters: Responsible for insulin-regulated glucose storage. Is the insulin -regulated glucose transporter.

It is plausible to propose that the modulation gljcosa GLUT4 is triggered by a combination of factors indicating cellular sensitiveness to insulin.

Effect of the thermogenic agent BRL A. Annu Rev Physiol ; Vesicular glutamate transporter 1 SLC32A1. All three monosaccharides glucosegalactoseand fructose are transported from the intestinal mucosal cell into the portal circulation by Glutx.

Horm Metab Res ; J Clin Invest ; Int J Obes ; These studies have revealed that, in DM2, the GLUT4 content is drastically reduced, playing an important role in insulin resistance. From Wikipedia, the free encyclopedia. Evidence for cytosolic sugar binding sites in erythrocytes”.


In Augustin Prague, Robert K. Whether mechanisms exist to promote cell-surface translocation of these transporters is not yet known, but it has clearly been established that insulin does not promote GLUT6 and GLUT8 cell-surface translocation.

Structure and function of mammalian facultative sugar transporters.

Loss of weight restores GLUT 4 content in insulin-sensitive tissues of monosodium glutamate-treated obese mice. Most members of classes II and III have been identified recently in homology searches of EST databases and the sequence information provided by the various genome projects. Molecular physiology of glucose transporters.

Proceedings of a Symposium held in Prague, August 22—27, It gluccosa also present in the basolateral membrane of the small intestine epithelium.

Tese – Mestrado -Escola Paulista de Medicina. Is glutz high-frequency and low-affinity isoform. Is a bidirectional transporter, allowing glucose to flow in 2 directions.

Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.

Decreased expression of glucose transporter in muscle from insulin-resistant patients. Comparison of kinetic parameters.